There are many factors that may lead to Insulin resistance. They range anywhere from toxins in the environment to lack of sleep. I will share just a fraction of them here. This condition relates to this natural hormone becoming less effective at lowering blood sugars and when...
...the blood sugar (glucose) rises above the normal range this may lead to Diabetes (if not already one) and damaged health. Fat and muscle cells need insulin to absorb glucose and when they don't get it - blood glucose levels rise.
The liver kicks in by reducing it's production of glucose in the presence of the hormone. This may not happen in people who are resistant.
Those considered pre-Diabetic (Metabolic Syndrome) usually experience high levels of the hormone and glucose. As this condition continues to exists, more insulin needs to be secreted by the pancreas. If this does not occur, blood glucose concentrations increase.
Some causes may include diet, cellular, molecular, genetic, and disease.
One major cause is increased amounts of fructose, saturated fats and excess calorie intake - this creates overweight and obesity conditions, this can especially be a problem when a large amount of fatty tissue is located in the abdomen.
Excessive insulin in the body also appears to be a contributor. This is due to prolonged and repeated increases in blood glucose. High carbohydrate intake is usually the cause.
The insulin drug itself can lead to this; when the cells are exposed to insulin, the production of glucose receptors (which include production of these receptors growing inside the blood vessels) on the cell's membrane decreases somewhat.
This decrease in the receptors signal the body to increase the need for insulin. Exercise reverses this process in muscle tissue, but if it is left unchecked, it can contribute to insulin resistance.
Also the body sometimes fights against the insulin drug by the production of antibodies which then leads to lower-than-expected glucose level reductions after a specific dose of insulin.
Certain disease can make the body resistant. A couple of examples include infection or acidosis. Treating insulin resistance includes exercise and weight loss and a decrease in high carbohydrate diets.
The Diabetes Prevention Program showed that exercise and diet were nearly twice as effective as some drugs at reducing the risk of progressing to type 2 diabetes.